Therapeutic Use of Cytokines to Modulate Phagocyte Function for the Treatment of Infectious Diseases: Current Status of Granulocyte Colony‐Stimulating Factor, Granulocyte‐Macrophage Colony‐Stimulating Factor, Macrophage Colony‐Stimulating Factor, and Interferon‐γ
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F EEDBACK REGU LATION OF COLONYSTIMULATING FACTOR PRODUCTION
The production of colony-stimulating factors (CSF) is delicately controlled through a complex network of humoral and environmental factors. We have studied some of the mechanisms which regulate the production of CSF as compared to general protein synthesis in the lung tissue ill vitro. When lung tissue from mice was cultured for various times in serum free medium, the first detectable le...
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Human monocytes, co-incubated for 7 days in culture with GM-CSF or IL-3 but not with IFN-gamma, exerted a variable schistosotnulicidal effect on Schistosoma mansoni parasites when grown in 96-well round-bottomed plates but not in flat-bottomed plates. Addition of LPS or IFN-gamma or both, for the last 48 h did not enhance the cidal effect. Addition of LPS but not IFN-gamma to the pre-incubated ...
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Polypeptide growth factors are involved in the regulation ofcell proliferation (1). These factors bind to specific receptors on the cell surface, stimulating the formation of intracellular second messengers that elicit a variety of responses . Transient increases in intracellular pH (2) and calcium concentration (3) can occur soon after growth factor addition . Other early responses induced by ...
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Dendritic cells (DC) 1 are class II-positive leukocytes specialized to initiate primary T cell-dependent immune responses (1-3) . DC were first identified in lymphoid tissues, and'most of the studies that have unraveled their unique stimulatory capacity for resting T cells used DC isolated from lymphoid organs . New insight into the biology of DC came from studies of murine epidermal Langerhans...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2002
ISSN: 0022-1899,1537-6613
DOI: 10.1086/340221